I would recommend submitting your home page to the major search engines individually, at least initially. However, there are several services that do groups of them for you - and is a big time saver for the rest of your site. The following is one of my favorites: FreeWebSubmission.com. I have always deselected Google, though, since I submit to them manually through the Google website. I submit my web pages to the following search engines manually (without a special tool) just to ensure that it is done.
You will need a Yahoo account to submit to the Yahoo search engine. And don't fret if you don't see immediate results. Your site should normally exist in MSN within about 6 weeks, in Yahoo in 8-12 weeks, and in Google within about 3 months. (You will not likely get much search results from Google for the first year though - but hold out and keep working on the other tricks. In the long run, Google will normally give you about 60 - 70% of the search engine traffïc if you follow these methods.)
Also, if you have the Alexa toolbar installed, navigate to your website and clïck on the "info" button on the toolbar. Then you will have to fill in information about your website. Once this is registered, you will start seeing how your website's Alexa rating looks. There have been some rumors that Google considers the Alexa description in its searches - so make sure it is relevant to your website as a whole and has at least one of your keywords.
You should also submit your website to DMOZ. This is a massive directory that is republished in several other websites. It is managed by humans, and is therefore considered to be of special relevance by other search engines. I strongly recommend reading all their rules before submitting - and follow them closely. Make sure that you try to get listed in only one category - the most relevant one for your business. It can take a month or two to get listed, but it really helps with your backlinks and overall relevancy as a website..